Viral transcriptional regulation

EBV Oncoproteins

Genome-wide studies of EBV nuclear antigens and latent membrane proteins that rewire B-cell transcription.

Overview

EBV Oncoproteins

EBV oncoproteins coordinate with host transcription factors to activate promoters and enhancers, alter chromatin states, and support lymphoblastoid cell growth. This project area focuses on the regulatory logic of EBNA-LP, EBNA2, EBNA3 proteins, and LMP1/LMP2A-driven programs.

  • EBNA-LP localization to promoters and enhancers with cell transcription factors and EBNA2.
  • EBNA3A and EBNA3C occupancy through BATF/IRF4 composite sites.
  • LMP1-mediated signaling through NF-kappaB and TRAF1 pathways.
  • Mouse and cell-line systems for EBV-driven lymphoproliferative biology.
EBV Oncoproteins figure

Publications

Related work

Representative publications connected to this project.

2018

Epstein-Barr Virus Nuclear Antigen Leader Protein coactivates EP300.

Wang C, Zhou H*, Xue Y, Liang J, Narita Y, Gerdt C, Zheng AY, Jiang R, Trudeau S, Peng CW, Gewurz BE.

J Virol. 2018;92(9):e02155-17.

2013

Epstein-Barr virus nuclear antigen leader protein localizes to promoters and enhancers with cell transcription factors and EBNA2.

Portal D*, Zhou H*, Zhao B, Kharchenko PV, Lowry E, Wong L, Quackenbush J, Holloway D, Jiang S, Lu Y, Kieff E.

Proc Natl Acad Sci U S A. 2013;110(46):18537-18542.

DOIPubMed
2017

Mouse model of Epstein-Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease.

Minamitani T, Ma Y, Zhou H, Kida H, Tsai CY, Obana M, Okuzaki D, Fujio Y, Kumanogoh A, Zhao B, Kikutani H.

Proc Natl Acad Sci U S A. 2017;114(18):4751-4756.