3D genome and regulatory networks

EBV Regulome

A systems-level view of how EBV regulatory elements, host enhancers, genes, and chromatin contacts coordinate lymphoblastoid cell programs.

Overview

EBV Regulome

The EBV regulome integrates enhancer maps, transcription factor occupancy, chromatin conformation, and gene expression to connect viral and host regulatory elements with target genes. This work helps explain how EBV reshapes host gene control and identifies regulatory dependencies in transformed B cells.

  • Constructed a comprehensive EBV regulome in lymphoblastoid cells.
  • Linked viral and cellular genes with enhancers through 3D genome organization.
  • Connected EBV enhancer looping with MYC regulatory control.
  • Provided a network view of EBV-associated transcriptional dependencies.
EBV Regulome figure

Publications

Related work

Representative publications connected to this project.

2017

The Epstein-Barr virus regulome in lymphoblastoid cells.

Jiang S, Zhou H*, Liang J, Gerdt C, Wang C, Ke L, Schmidt SC, Narita Y, Ma Y, Wang S, Colson T.

Cell Host Microbe. 2017;22(4):561-573.

2020

Epstein-Barr virus episome physically interacts with active regions of the host genome in lymphoblastoid cells.

Wang L, Laing J, Yan B, Zhou H, Ke L, Wang C, Narita Y, Zhang Z, Olson MR, Afzali B, Zhao B.

J Virol. 2020;94(24):e01390-20.

2015

Epstein-Barr virus oncoprotein super-enhancers control B cell growth.

Zhou H, Schmidt SC, Jiang S, Willox B, Bernhardt K, Liang J, Johannsen EC, Kharchenko P, Gewurz BE, Kieff E, Zhao B.

Cell Host Microbe. 2015;17(2):205-216.

DOIPubMed