Interfaces between infection and computation

Host-Pathogen PPIs

Prediction of interactions between host and pathogen proteins to generate hypotheses about infection mechanisms and potential targets.

Overview

Host-Pathogen PPIs

Host-pathogen interaction prediction is difficult because protein interfaces, evolutionary distance, and pathogen-specific biology all matter. This work emphasizes stringent prediction rules and interpretable network analysis for H. sapiens-M. tuberculosis interactions.

  • Developed stringent homology-based prediction of human-M. tuberculosis protein interactions.
  • Incorporated differences between eukaryotic and prokaryotic proteins and between inter-species and intra-species interaction interfaces.
  • Analyzed host and pathogen hub proteins in predicted interaction networks.
  • Generated hypotheses for infection biology and target prioritization.
Host-Pathogen PPIs figure

Publications

Related work

Representative publications connected to this project.

2014

Stringent homology-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions.

Zhou H, Gao S, Nguyen NN, Fan M, Jin J, Liu B, Zhao L, Xiong G, Tan M, Li S, Wong L.

Biol Direct. 2014;9:5.

DOI
2013

Progress in computational studies of host-pathogen interactions.

Zhou H, Jin J, Wong L.

J Bioinform Comput Biol. 2013;11(2):1230001.