Computational systems biology

Protein-Protein Interactions

Computational prediction, assessment, and biological interpretation of protein-protein interaction networks.

Overview

Protein-Protein Interactions

Protein interaction networks provide hypotheses for biological function, host-pathogen mechanisms, and drug-target discovery. This project area includes homology-based and domain-domain-interaction approaches, quality assessment of interaction datasets, and pathway-level integration.

  • Predicted H. sapiens-M. tuberculosis H37Rv host-pathogen interactions using stringent homology-based methods.
  • Evaluated M. tuberculosis H37Rv protein interaction datasets for reliability and utility.
  • Developed domain-informed approaches to improve PPI prediction specificity.
  • Integrated pathway and functional data through IntPath and related tools.
Intra-Species PPIsHost-Pathogen PPIsProtein Functions and Pathways
Protein-Protein Interactions figure

Publications

Related work

Representative publications connected to this project.

2014

Stringent homology-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions.

Zhou H, Gao S, Nguyen NN, Fan M, Jin J, Liu B, Zhao L, Xiong G, Tan M, Li S, Wong L.

Biol Direct. 2014;9:5.

DOI
2011

Comparative analysis and assessment of M. tuberculosis H37Rv protein-protein interaction datasets.

Zhou H, Wong L.

BMC Genomics. 2011;12 Suppl 3:S20.

2013

Progress in computational studies of host-pathogen interactions.

Zhou H, Jin J, Wong L.

J Bioinform Comput Biol. 2013;11(2):1230001.